Laurenţiu Spiridon, PhD
Researcher in the Bioinformatics and Structural Biochemistry Group,
Institute of Biochemistry of the Romanian Academy

♦ C,C++ programming ♦ Protein-protein docking ♦ Molecular modeling and simulation

Thesis Title:

Protein Structure and Post-translational Modifications Investigation Using Bioinformatics

Contact: ;


11.   Slootweg EJ, Spiridon LN, Roosien J, Butterbach P, Pomp R, Westerhof L, Wilbers R, Bakker E, Bakker J, Petrescu AJ, Smant G, Goverse A, "Structural Determinants at the Interface of ARC2 and LRR Domains Control the Activation of the NB-LRR Plant Immune Receptors Rx1 and Gpa2", Plant Physiology;: Epub ahead of print, 2013,
PMID: [23660837]


10.   Ciubotaru M, Trexler AJ, Spiridon LN, Surleac MD, Rhoades E, Petrescu AJ and Schatz DG, "RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complex", Nucleic Acids Research;: Epub ahead of print, 2013,
PMID: [23293004]


9.   Marin MB, Ghenea S, Spiridon LN, Chiritoiu GN, Petrescu AJ, Petrescu SM., "Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.", PLoS One; 7(8): e42998, 2012,
PMID: [22905195]


8.   Sela H, Spiridon LN, Petrescu AJ, Akerman M, Mandel-Gutfreund Y, Nevo E, Loutre C, Keller B, Schulman AH, Fahima T., "Ancient diversity of splicing motifs and protein surfaces in the wild emmer wheat (Triticum dicoccoides) LR10 coiled coil (CC) and leucine-rich repeat (LRR) domains.", Mol Plant Pathol; 13(3): 276-87, doi: 10.1111/j.1364-3703.2011.00744.x., 2012,
PMID: [21952112]


7.   Cioaca D#, Ghenea S#, Spiridon LN#, Marin M#, Petrescu AJ*, Petrescu SM*., "C-terminus glycans with critical functional role in the maturation of secretory glycoproteins.", PLoS One.;6(5):e19979. 2011
PMID: [21625599]


6.   Maekawa T, Cheng W, Spiridon LN, Toller A, Lukasik E, Saijo Y, Liu P, Shen QH, Micluta MA, Somssich IE, Takken FL, Petrescu AJ, Chai J, Schulze-Lefert P., "Coiled-coil domain-dependent homodimerization of intracellular barley immune receptors defines a minimal functional module for triggering cell death.", Cell Host Microbe.;9(3):187-99. 2011
PMID: [21402358]


5.   Slootweg E, Roosien J, Spiridon LN, Petrescu AJ, Tameling W, Joosten M, Pomp R, van Schaik C, Dees R, Borst JW, Smant G, Schots A, Bakker J, Goverse A., "Nucleocytoplasmic distribution is required for activation of resistance by the potato NB-LRR receptor Rx1 and is balanced by its functional domains.", Plant Cell.;22(12):4195-215. 2010
PMID: [21177483]


4.   Balasu MC, Spiridon LN, Miron S, Craescu CT, Scheidig AJ, Petrescu AJ, Szedlacsek SE., "Interface analysis of the complex between ERK2 and PTP-SL.", PLoS One.;4(5):e5432, 2009
PMID: [19424502]


3.   Rehman S, Postma W, Tytgat T, Prins P, Qin L, Overmars H, Vossen J, Spiridon LN, Petrescu AJ, Goverse A, Bakker J, Smant G., "A secreted SPRY domain-containing protein (SPRYSEC) from the plant-parasitic nematode Globodera rostochiensis interacts with a CC-NB-LRR protein from a susceptible tomato.", Mol Plant Microbe Interact.; 22(3):330-40. 2009
PMID: [19245327]


2.   Kammenga JE, Doroszuk A, Riksen JA, Hazendonk E, Spiridon L, Petrescu AJ, Tijsterman M, Plasterk RH, Bakker J.,"A Caenorhabditis elegans Wild Type Defies the Temperature–Size Rule Owing to a Single Nucleotide Polymorphism in tra-3", PLoS genetics, 3(3), e34, 2007
PMID: [17335351]


1.   Paduraru C, Spiridon L, Yuan W, Bricard G, Valencia X, Porcelli SA, Illarionov PA, Besra GS, Petrescu SM, Petrescu AJ, Cresswell P., "An N-linked glycan modulates the interaction between the CD1d heavy chain and beta 2-microglobulin.", J Biol Chem.; 281(52):40369-78, 2006
PMID: [17071611]


0.   Acknoledged in:
Takken FLW, Goverse A, "How to build a pathogen detector: structural basis of NB-LRR function", Curr Opin Plant Biol.;15(4): 375-84, 2012
PMID: [22658703]

- Non-ISI -

Munteanu CVA, Alexandru P, Spiridon LN, Petrescu AJ, Milac AL, "Insights into cecropin-membrane interaction mechanism given by molecular dynamics simulations.", Romanian Journal of Biochemistry, 49(1), 21-31, 2012


PBE Butterbach, EJ Slootweg, KB Koropacka, JCP Prins, J Roosien, L Spiridon, A Petrescu, G Smant, EH Bakker, J Bakker, A Goverse, "Functional contraints and evolutionary dynamics of the Rx1/Gpa2 cluster in potato", Biology of plant-microbe interactions, 6, 2008


Surleac MD, Spiridon LN, Tacutu R, Milac AL, Pestrescu SM, Petrescu AJ, "The Structural Assessment of Glycosylation Sites Database - SAGS - An Overall View on N-Glycosylation.", Glycosylation, cap. 1, 2012